BDTH2 (N,N′-bis-(2-mercaptoethyl) isophthalamide, NBMI, emeramide) is a thiol-redox antioxidant and metal chelator. The drug penetrates cell membranes, crosses the blood-brain barrier, and has antioxidant properties for scavenging and reducing the toxicity levels of hydroxyl free radicals, which are dangerous for the cells’ normal redox status (1).
Also, at least in vitro, BDTH2 appears to selectively chelate arsenic ions and other toxic and non-essential metals such as lead, cadmium, and uranium without evidence of toxicity. BDTH2 is based on carboxyl benzoate with two arms made of cysteamine moieties attached to the aromatic ring’s 1st and 3rd carbon groups. The two sulfhydryl groups of cysteamines are free to flex and rotate to accommodate several toxic soft acid metal ions. So far, clinical trials of BDTH2 have shown no adverse effects in humans (1).
1. Bjørklund G, Oliinyk P, Lysiuk R, Rahaman MS, Antonyak H, Lozynska I, Lenchyk L, Peana M. Arsenic intoxication: general aspects and chelating agents. Arch Toxicol 2020; 94: 1879-1897.