CNS Health: Pain and Discomfort
Product Candidate
Podaflex Capsules
Podaflex Capsules is a dietary supplement developed to support joint comfort, particularly in the feet and lower limbs. Discomfort in the big toe joint and surrounding structures is often linked to mechanical load, lifestyle factors, and local inflammatory responses and can limit walking and daily activities.
Podaflex combines botanical extracts that have a long history of traditional use for joints and musculoskeletal comfort. Each capsule contains 300 mg of Curcuma longa (turmeric), 200 mg of Boswellia serrata (Boswellia), 150 mg of Zingiber officinale (ginger), 100 mg of Salix alba bark (white willow), and 10 mg of Piper nigrum (black pepper; standardized to 95% piperine).
Curcumin, the main active constituent of turmeric, has been investigated in experimental and clinical studies for its anti-inflammatory and antioxidant properties. It is known to interact with cellular signalling pathways involved in the body’s inflammatory response and oxidative stress, and is widely used in supplements aimed at supporting joint comfort and mobility.
Boswellia serrata provides boswellic acids, which have been studied for their ability to influence mediators of inflammation and for their potential relevance to cartilage metabolism and joint function. Through these mechanisms, Boswellia extracts are used in formulations intended to help maintain joint flexibility and comfort.
Zingiber officinale (ginger) contains gingerols and related compounds that have been examined for their anti-inflammatory and analgesic properties. Ginger is traditionally consumed to support musculoskeletal comfort and has been evaluated in human studies for its potential to help maintain joint function and ease everyday discomfort.
Salix alba bark is a natural source of salicin, a compound that has been associated with relief of mild pain and support of musculoskeletal comfort in traditional use. Extracts of white willow bark have been studied for their influence on prostaglandin pathways and their role in supporting the body’s response to minor pain and strain.
Piper nigrum (black pepper) standardized to 95% piperine is included to support the bioavailability of certain plant constituents. Piperine has been shown to influence metabolic enzymes and transporters, which can enhance the absorption of some co-administered compounds, including curcumin.
Together, these ingredients form a formula intended to support joint function, mobility, and comfort in the feet and lower limbs as part of a balanced lifestyle. Podaflex Capsules are a non-prescription supplement and are not intended to diagnose, treat, cure, or prevent disease; they are designed to be used alongside appropriate medical care and lifestyle measures where needed.