Thymosin beta-4: A Possible New Medicine for Multiple Sclerosis?
While significant progress has been made in treating multiple sclerosis (MS) with the development of immunomodulatory and anti-inflammatory therapies, regenerative therapy would provide MS patients with a new tool to treat their disease. Research indicates that thymosin beta-4 (Tβ4) can potentially treat MS in people at both early and late stages, possibly alone or in combination with existing therapies. Tβ4 has also improved functional outcomes in a rodent model of embolic stroke (1) and trauma (2).
Tβ4 increased myelinated axons and angiogenesis in these studies in the ischemic boundary and augmented re-myelination. There was also an increase in oligodendrocyte progenitor cells and myelinating oligodendrocytes. The repair process after stroke and trauma parallels that in the heart after myocardial infarction, where Tβ4 promotes cardiomyocyte survival and improved cardiac function by recruiting stem/progenitor cells and reducing inflammation and scar production (3). Tβ4 has the potential to control inflammatory processes in the brain, which opens avenues for new therapeutic applications to a range of neurodegenerative conditions (4).
1. Morris DC, Chopp M, Zhang L, et al. Thymosin Tbeta4 improves functional neurological outcome in a rat model of embolic stroke. Neuroscience 2010;169:674-82.
2. Xiong Y, Mahmood A, Meng Y, et al. Treatment of traumatic brain injury with thymosin beta4 in rats. J Neurosurg 2011;114:102-15.
3. Bjørklund G, Dadar M, Aaseth J, Chirumbolo S. Thymosin β4: A Multi-Faceted Tissue Repair Stimulating Protein in Heart Injury. Curr Med Chem 2020;27:6294-305.
4. Pardon MC. Share Anti-inflammatory potential of thymosin β4 in the central nervous system: implications for progressive neurodegenerative diseases. Expert Opin Biol Ther 2018;18(sup1):165-9. doi: 10.1080/14712598.2018.1486817.
Inbio NeuroVita is a specialized dietary supplement to support neurological health and enhance cognitive function. The natural ingredients in the product aim to promote optimal brain function, nervous system health, and emotional well-being. NeuroVita combines key nutrients, each with unique properties that have been studied for potential benefits in supporting neurological health.
Each capsule of Inbio NeuroVita contains 50 mg of vitamin B6 (pyridoxine), 200 mg magnesium (as magnesium citrate), 1000 IU (25 mcg) vitamin D (as cholecalciferol), 500 mg omega-3 fatty acids (from fish oil, providing at least 200 mg EPA and 100 mg DHA).
Inbio NeuroVita is indicated for individuals seeking to support their neurological health, enhance cognitive function, and maintain emotional balance. It is particularly beneficial for individuals experiencing mild stress, occasional anxiety or those looking to optimize their brain health. Inbio NeuroVita can be a valuable addition to individuals’ daily routines striving for overall well-being and supporting a healthy nervous system.
Vitamin B6 (pyridoxine) is crucial in neurotransmitter synthesis, contributing to healthy brain function and cognitive performance. Magnesium (as magnesium citrate) supports nerve transmission and muscle function, which is essential for maintaining a healthy nervous system. Vitamin D (as cholecalciferol) helps regulate brain development and function, and its deficiency may impact neurological health. Omega-3 fatty acids (from fish oil) are rich in EPA and DHA, vital components of brain cell membranes, supporting brain health and cognitive function.
For children, follow the healthcare professional’s guidance on the appropriate dosage of Inbio NeuroVita based on age, weight, and health needs. Follow-up visits may be needed for monitoring and adjusting the treatment plan. Discontinue use if adverse reactions occur and maintain open communication with the healthcare provider for optimal results.
For adults, the recommended dosage of Inbio NeuroVita is one capsule daily, taken with a meal or as directed by a healthcare professional. Swallow the capsule whole with a glass of water, and do not exceed the suggested dosage unless advised otherwise by a healthcare professional.
Inbio NeuroVita is not recommended for individuals with known allergies to its ingredients. Pregnant or nursing women should consult a healthcare professional before using this supplement. Individuals with pre-existing medical conditions or those taking other medications should consult a healthcare professional before starting this supplement.
Inbio NeuroVita is intended for dietary supplementation and should not be used as a substitute for a varied and balanced diet or a healthy lifestyle. This product is not intended to diagnose, treat, cure, or prevent any disease.
Inbio Neurona is a natural dietary supplement that supports neurological health and optimizes cognitive function. The formulation includes 5-hydroxytryptophan (5-HTP), a natural substance derived from the African plant Griffonia simplicifolia seeds. Combined with vitamin B6, 5-HTP plays a crucial role in synthesizing serotonin, a neurotransmitter associated with positive mood and enhanced energy levels.
Inbio Neurona supports neurological health and function, enhances cognitive performance and focus, and promotes positive mood and emotional well-being.
For adults, the recommended dosage is one capsule of Inbio Neurona daily, preferably taken with a glass of water. It is essential to adhere to the recommended dosage unless otherwise advised by a healthcare professional.
Inbio Neurona is not recommended for individuals with known allergies to its ingredients. Pregnant or nursing women should consult a healthcare professional before using this supplement.
Store the product at a temperature not exceeding 25°C. Keep out of the reach of children. In cases of higher than recommended intake, temporary gastrointestinal discomfort, such as diarrhea, may occur.
Each capsule of Inbio Neurona contains 150 mg Griffonia simplicifolia seed powder (containing 12 mg of L-5-hydroxytryptophan), vitamin B6 (0.35 mg; 25% of recommended daily intake), and 0.275 mg thiamine (Vitamin B1; 25% of recommended daily intake). In addition to the active ingredients, Inbio Neurona contains capsule shells (gelatin, iron oxides), cellulose (bulking agent), calcium phosphates (anti-caking agents), magnesium stearate, and silicon dioxide.
Inbio Neurona is intended for dietary supplementation and should not replace a balanced diet or healthy lifestyle. This product is not intended to diagnose, treat, cure, or prevent any disease.