In dermatology, Björklund Pharma presents innovative skincare solutions: InBio Paeonol + Zinc for inflammatory skin conditions, and InBio Vital Skin, which combines phenylthiol hydroxyether with essential nutrients for antioxidant protection, collagen stimulation, and improved skin texture. Phenylthiol hydroxyether contributes antimicrobial and barrier-enhancing properties, while thymosin beta 4 demonstrates promise in reducing healing time.
Product Candidates
InBio Paeonol + Zinc
InBio Paeonol + Zinc is a dermatological ointment formulated with natural ingredients renowned for their therapeutic efficacy in managing inflammatory skin conditions. The product includes paeonol extract, zinc oxide, aloe vera gel, shea butter, and olive oil. Paeonol, derived from Paeonia suffruticosa, possesses potent anti-inflammatory and antioxidant properties that help soothe and reinforce the skin barrier, making it particularly beneficial for eczema and dermatitis.
Zinc oxide is known for its antimicrobial and wound-healing effects, supporting skin regeneration and reducing redness and discomfort associated with inflammatory conditions. Aloe vera gel hydrates the skin, accelerates wound healing, and alleviates itching and irritation. Shea butter nourishes and fortifies the skin’s natural barrier, ideal for dry and sensitive skin types. Olive oil shields and replenishes the skin, enhancing elasticity and supporting repair processes.
The synergistic action of these natural ingredients in InBio Paeonol + Zinc offers a holistic approach to calming and fortifying inflamed skin. This formulation is suitable for individuals affected by eczema, dermatitis, or pruritus, providing gentle yet effective relief for sensitive and irritated skin. For topical application, apply a thin layer to affected areas and gently massage until absorbed, avoiding contact with eyes or mucous membranes. If skin irritation occurs, discontinue use and consult with a healthcare professional.
InBio Vital Skin: Advanced Anti-Aging Formula
InBio Vital Skin is an advanced anti-aging formula that combines phenylthiol hydroxyether (C6H5-SH | C6H5-O-C6H5-OH | -OH) with essential nutrients, including vitamin E, hyaluronic acid, peptides, resveratrol, coenzyme Q10, niacinamide, and green tea extract. This synergistic blend provides antioxidant protection, boosts collagen production, improves skin texture, and enhances hydration.
InBio Vital Skin is a lightweight moisturizing gel or lotion designed to improve skin quality and resilience.
Phenylthiol Hydroxyether: Dermatological Potential
Phenylthiol hydroxyether, characterized by a phenyl ring linked to a thiol (-SH) group, hydroxyl (-OH) groups, and ether (-O-) functionalities, demonstrates dermatological applications. This compound exhibits antimicrobial activity beneficial for acne management, enhances skin barrier integrity, and functions as an efficient vehicle for topical drug delivery in skincare formulations.
The multifaceted properties of phenylthiol hydroxyether underscore its potential as a versatile component in dermatological therapeutics.
Spongiderm
Spongiderm, a product candidate from Björklund Pharma, utilizes compounds from the freshwater lake sponge Spongilla lacustris to treat moderate to severe acne, mild to moderate psoriasis, and moderate to severe rosacea. The sponge’s silica spicules exfoliate the skin, stimulate collagen production, and unclog pores while enhancing the delivery of antimicrobial and anti-inflammatory compounds like spongin and bioactive silica.
Research shows the compounds in Spongiderm effectively reduce inflammation and bacteria, targeting acne-causing Cutibacterium acnes. With a once-weekly application, Spongiderm offers a potentially faster and more effective treatment for inflammatory skin conditions than existing products.
Thymosin Beta 4 in Dermal Healing
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Unlike many pharmacological treatments for various pathologies, much is known about the mechanisms of action of thymosin beta 4 (Tβ4). The active site(s), receptor, signaling pathways, and biological activities are known. The safety profile is excellent, and no preclinical toxicology has been found (1).
Efficacy trends have been observed in phase 2 clinical trials, which reduced the healing time by almost half. Also, a near-optimal dose (0.02–0.03%, w/w) has been identified in dosing studies for dermal healing. Finally, no adverse reactions have been observed with topical or injected Tβ4 in humans, and no autoantibodies have been detected. Tβ4 is a naturally occurring molecule that relatively cheaply can be synthesized. The cost is important given that other treatments are not widely used due to the high cost and limited efficacy (1).
Reference
- Kleinman HK, Sosne G. Thymosin β4 promotes dermal healing. Vitam Horm 2016;102:251-75. doi: 10.1016/bs.vh.2016.04.005.