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Metal-Induced Inflammation Triggers Fibromyalgia in Metal-Allergic Patients

December 8, 2014 By admin

Vera Stejskal, Karin Öckert, and Geir Bjørklund studied the frequency and clinical relevance of metal allergy in 15 fibromylagia (FM) patients (1). Metal allergy was measured by a lymphocyte transformation test, MELISA®. Ten healthy age matched women were used as controls. Reduction of metal exposure in the FM patients was achieved by replacement of dental metal restorations and by the avoidance of known sources of metal exposure. Objective health assessment was performed 5 years after treatment. Subjective health assessment was established by a questionnaire, completed 2, 5 and in some cases 10 years after the start of the study. Follow-up MELISA was also performed. All FM patients tested positive to at least one of the metals tested. Objective examination 5 years later showed that half of the patients no longer fulfilled the FM diagnosis, 20% had improved and the remaining 30% still had FM. All patients reported subjective health improvement.

Vera Stejskal is Associate Professor of Immunology at University of Stockholm, Sweden. She is founder and president of the MELISA Medica Foundation. Karin Öckert is a pensioned Swedish dentist/specialist in periodontics.

Reference
1. Stejskal V, Öckert K, Bjørklund G. Metal-induced inflammation triggers fibromyalgia in metal-allergic patients. Neuro Endocrinol Lett 2013; 34: 559-565.

 

Filed Under: Company News, Research News Tagged With: Fibromyalgia, MELISA, Mercury, Metal Allergy, Metals, Nickel

The Role of Zinc and Copper in Autism Spectrum Disorders

December 8, 2014 By admin

Acta-Neurobiol-Exp-2013-2Children with Autism spectrum disorders (ASDs) appear to be at risk for zinc (Zn) deficiency, copper (Cu) toxicity, have often low Zn/Cu ratio, and often disturbed metallothionein (MT) system functioning. The evidence presented in this paper suggests that providing Zn to autistic children may be an important component of a treatment protocol, especially in children with Zn deficiency. It is important to monitor and follow the values for both Cu and Zn together during Zn therapy, because these two trace elements are both antagonists in function, and essential for living cells. 

The review article by Geir Bjørklund is published in Acta Neurobiologiae Experimentalis (2013; 73 (2): 225–236). This peer-reviewed journal is published by Nencki Institute of Experimental Biology in Warsaw, Poland.

 

Geir Bjørklund

The role of zinc and copper in autism spectrum disorders

Acta Neurobiol Exp (Wars) 2013; 73 (2): 225-236 

 

ABSTRACT

Autism spectrum disorders (ASDs) are a group of developmental disabilities that can cause significant social, communication and behavioral challenges. Several studies have suggested a disturbance in the copper (Cu) and zinc (Zn) metabolism in ASDs. Zinc deficiency, excess Cu levels, and low Zn/Cu ratio are common in children diagnosed with an ASD. The literature also suggests that mercury accumulation may occur as a cause or consequence of metallothionein (MT) dysfunction in children diagnosed with an ASD, which may be one of the causes of Zn deficiency. MTs are proteins with important functions in metal metabolism and protection. Zinc and Cu bind to and participate in the control of the synthesis of MT proteins. Studies indicate that the GABAergic system may be involved in ASDs, and that Zn and Cu may play a role in this system.

 

Filed Under: Company News, Research News Tagged With: Autism, Brain, Copper, Mercury, Zinc

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