Regenerative medicine represents an emerging approach to chronic and life-threatening conditions by developing therapies that aim to replace or regenerate human cells, tissues, or organs to restore function. Björklund Pharma is advancing research in this field with a focus on thymosin beta-4 (Tβ4), a peptide with well-documented properties that support tissue repair and healing. Tβ4 promotes cell migration, differentiation, and angiogenesis (the formation of new blood vessels), and is being evaluated as a candidate in regenerative medicine.
Tβ4 Overview
Tβ4 is a naturally occurring peptide involved in tissue regeneration. By binding to actin, it facilitates cell migration and supports natural healing processes across a range of tissues and cell types. Björklund Pharma is exploring the therapeutic and commercial potential of Tβ4 across multiple medical fields to address unmet clinical needs. Read More
Therapeutic Applications
Neurology
Tβ4 is being investigated for its potential role in multiple sclerosis, a chronic condition affecting the central nervous system. Preclinical studies in rodent models suggest that Tβ4 can increase myelinated axons, enhance angiogenesis, and stimulate the proliferation of oligodendrocyte progenitor cells, indicating possible neuroprotective and regenerative effects. Read More
Cardiology
The heart’s limited regenerative capacity presents challenges in managing cardiac injuries. Research suggests that Tβ4 may promote angiogenesis and recruit stem/progenitor cells to damaged tissues, potentially facilitating heart tissue repair, supporting cardiac function, and limiting scar formation in preclinical settings. Read More
Dermatology
Tβ4 supports dermal repair by promoting cell migration and tissue regeneration. These properties make it a candidate under investigation for inflammatory skin conditions, wound healing, and aesthetic or anti-aging applications. Read More
Ophthalmology
In ophthalmology, Tβ4 shows potential for dry eye syndrome and other ocular surface disorders. It enhances corneal epithelial cell migration and reduces inflammation in experimental models, suggesting a possible role in supporting ocular surface health. Read More
Pulmonology
Research highlights Tβ4’s role in mitigating pulmonary fibrosis and promoting lung tissue repair. It reduces inflammation, modulates TGF-β signaling, and limits excessive scarring in preclinical models, with potential relevance for idiopathic pulmonary fibrosis (IPF) and acute respiratory distress syndrome (ARDS). Read More
Gastroenterology
Tβ4’s regenerative and anti-inflammatory properties are being explored for gastrointestinal conditions. Studies suggest that Tβ4 promotes intestinal epithelial repair, reduces inflammation, and supports mucosal healing, highlighting its potential relevance for Crohn’s disease, ulcerative colitis, and other inflammatory bowel diseases. Read More
Musculoskeletal Repair
Tβ4 facilitates the regeneration of tendons, ligaments, and cartilage by promoting cell migration, collagen deposition, and reducing inflammation. These effects make it a promising candidate under investigation for osteoarthritis, sports-related injuries, and postoperative recovery. Read More
Immunology
Tβ4 exhibits immunomodulatory properties, including regulation of macrophage activity and suppression of pro-inflammatory cytokines such as TNF-α and IL-1β. It is being studied as a potential agent in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus (SLE). Read More
Infectious Diseases
The COVID-19 pandemic highlighted the need for innovative approaches to managing severe complications. Preliminary research and mechanistic models suggest that Tβ4’s anti-inflammatory and fibrinolytic properties may help modulate blood clot formation, inflammation, and tissue damage, indicating potential applicability in COVID-19–related complications and other severe infectious diseases, subject to further rigorous investigation. Read More