Regenerative medicine aims to restore function by activating or supplementing biological pathways involved in tissue repair. Björklund Pharma is advancing research centered on thymosin beta-4 (Tβ4), a peptide under evaluation for regenerative and cytoprotective activity in preclinical settings, including effects on cell migration and vascular remodeling.
Tβ4 Overview
Tβ4 is a naturally occurring peptide associated with actin dynamics and repair-related cellular responses. Björklund Pharma is exploring its translational potential through a programmatic focus on defined indications in which tissue injury, impaired repair, and inflammatory remodeling contribute to disease biology. Read More
Therapeutic Applications
Neurology
Tβ4 is under investigation for neurorepair and neuroprotection in demyelinating and neuroinflammatory conditions, including multiple sclerosis. Preclinical studies in rodent models report effects consistent with remyelination-associated biology, vascular responses, and oligodendrocyte lineage dynamics, supporting further evaluation. Read More
Cardiology
Cardiac injury is characterized by limited regenerative capacity and maladaptive remodeling. Preclinical research suggests Tβ4 may influence vascular responses and progenitor-cell–associated repair pathways, supporting evaluation in models of myocardial injury and post-injury remodeling. Read More
Dermatology
Tβ4 is being evaluated for its role in dermal repair biology, including epithelial migration and tissue remodeling, with relevance to wound healing and inflammatory skin conditions in preclinical and translational settings. Read More
Ophthalmology
Ocular surface disorders involve epithelial injury and inflammatory signaling. Experimental models suggest Tβ4 may support corneal epithelial repair and modulate inflammatory responses, supporting continued evaluation in dry eye and related conditions. Read More
Pulmonology
Tissue injury and fibrotic remodeling are central features of several severe pulmonary disorders. Preclinical findings suggest Tβ4 may modulate inflammatory pathways and repair-associated signaling, including processes relevant to fibrosis and scarring, supporting evaluation in models of pulmonary injury. Read More
Gastroenterology
Mucosal integrity and epithelial regeneration are critical for recovery in inflammatory bowel disease and related gastrointestinal conditions. Studies indicate that Tβ4 may support epithelial repair, reduce inflammatory signaling, and promote mucosal healing in experimental models, supporting continued translational assessment. Read More
Musculoskeletal Repair
Repair of tendons, ligaments, and cartilage depends on coordinated regeneration and remodeling. Preclinical studies suggest Tβ4 may influence cell migration, extracellular matrix organization, and inflammation-related pathways relevant to recovery after injury and degenerative change. Read More
Immunology
Tβ4 has been reported to influence immune signaling, including macrophage-associated responses and regulation of inflammatory mediators such as TNF-α and IL-1β. These immunomodulatory features support exploratory evaluation in immune-mediated and autoimmune disorders where tissue remodeling and chronic inflammation intersect. Read More
Infectious Diseases
Severe infections can involve inflammatory injury, vascular dysfunction, and downstream tissue damage. Mechanistic hypotheses and preliminary data suggest Tβ4-related modulation of injury pathways; any potential applicability remains exploratory and requires rigorous validation. Read More