Thymosin beta-4 (Tβ4) is a highly conserved, naturally occurring water-soluble regenerative peptide found in all tissues and cell types, except red blood cells. It binds to actin and promotes cell migration, including the mobilization, migration, and differentiation of stem/progenitor cells, new blood vessel forming, and tissue regenerating. Tβ4 also decreases the number of myofibroblasts in wounds, reducing scar formation and fibrosis.
Geir Bjørklund et al. published 2020 a review about the promising role of Tβ4 in cardiac healing (1). Other researchers’ investigation of Tβ4 includes the treatment of dry eye syndrome, diabetes, and pressure ulcers (i.e., pressure sores or bedsores). Nowadays, Björklund Pharma AS further evaluates the therapeutic and commercial potential of Tβ4.
1. Bjørklund G, Dadar M, Aaseth J, Chirumbolo S. Thymosin β4: a multi-faceted tissue repair stimulating protein in heart injury. Curr Med Chem 2020; 27(37): 6294-6305.